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Zoloft is designed to help those who suffer from depression, anxiety, Side effects of doxycycline hyclate or obsessive compulsive disorder. It is part Side effects of doxycycline hyclate a class of drugs called selective serotonin reuptake inhibitors. The mechanism by which Zoloft works is not fully understood although what researchers do know is that it works by increasing the level of serotonin in the brain by inhibiting its breakdown.